Les nouveaux immortels : le succès des séries télévisées fantastiques destinées au public adolescent

Naissance du genre " fantastique pour adolescents " dans les séries télévisées des années 1990, représentation de cet âge confrontée au vieillissement des acteurs

CDKN1B/p27 regulates autophagy via the control of Ragulator and MTOR activity in amino acid-deprived cells

The tumor suppressor CDKN1B/p27Kip1 binds to and inhibits cyclin-CDK complexes in the nucleus, inducing cell cycle arrest. However, when in the cytoplasm, CDKN1B may promote tumorigenesis. Notably, cytoplasmic CDKN1B was reported to promote macroautophagy/autophagy in response to nutrient shortage by a previously unknown mechanism. In our recent work, we found that during prolonged amino acid starvation, CDKN1B promotes autophagy via an MTORC1-dependent pathway. A fraction of CDKN1B translocates to lysosomes, where it interacts with the Ragulator subunit LAMTOR1, preventing Ragulator assembly, which is required for MTORC1 activation in response to amino acids. Therefore, CDKN1B represses MTORC1 activity, leading to nuclear translocation of the transcription factor TFEB and activation of lysosomal function, enhancing starvation-induced autophagy flux and apoptosis. In contrast, cells lacking CDKN1B survive starvation despite reduced autophagy, due to elevated MTORC1 activation. These findings reveal that, by directly repressing MTORC1 activity, CDKN1B couples the cell cycle and cell growth machineries during metabolic stress

From vertex detectors to inner trackers with CMOS pixel sensors

The use of CMOS Pixel Sensors (CPS) for high resolution and low material vertex detectors has been validated with the 2014 and 2015 physics runs of the STAR-PXL detector at RHIC/BNL. This opens the door to the use of CPS for inner tracking devices, with 10-100 times larger sensitive area, which require therefore a sensor design privileging power saving, response uniformity and robustness. The 350 nm CMOS technology used for the STAR-PXL sensors was considered as too poorly suited to upcoming applications like the upgraded ALICE Inner Tracking System (ITS), which requires sensors with one order of magnitude improvement on readout speed and improved radiation tolerance. This triggered the exploration of a deeper sub-micron CMOS technology, Tower-Jazz 180 nm, for the design of a CPS well adapted for the new ALICE-ITS running conditions. This paper reports the R&D results for the conception of a CPS well adapted for the ALICE-ITS.Comment: 4 pages, 4 figures, VCI 2016 conference proceeding

Simulation of a Hybrid Optical/Radio/Acoustic Extension to IceCube for EeV Neutrino Detection

Astrophysical neutrinos at $\sim$EeV energies promise to be an interesting source for astrophysics and particle physics. Detecting the predicted cosmogenic (``GZK'') neutrinos at 10$^{16}$ - 10$^{20}$ eV would test models of cosmic ray production at these energies and probe particle physics at $\sim$100 TeV center-of-mass energy. While IceCube could detect $\sim$1 GZK event per year, it is necessary to detect 10 or more events per year in order to study temporal, angular, and spectral distributions. The IceCube observatory may be able to achieve such event rates with an extension including optical, radio, and acoustic receivers. We present results from simulating such a hybrid detector.Comment: 4 pages, 2 figures; to appear in the Proceedings of the 29th ICRC, Pune, Indi

Comprehensive analysis of anomalous ANITA events disfavors a diffuse tau-neutrino flux origin

Recently, the ANITA collaboration reported on two upward-going extensive air shower events consistent with a primary particle that emerges from the surface of the Antarctic ice sheet. These events may be of ντ origin, in which the neutrino interacts within the Earth to produce a τ lepton that emerges from the Earth, decays in the atmosphere, and initiates an extensive air shower. In this paper we estimate an upper bound on the ANITA acceptance to a diffuse ντ flux detected via τ-lepton-induced air showers within the bounds of standard model uncertainties. By comparing this estimate with the acceptance of Pierre Auger Observatory and IceCube and assuming standard model interactions, we conclude that a ντ origin of these events would imply a neutrino flux at least two orders of magnitude above current bounds

Relativistic Magnetic Monopole Flux Constraints from RICE

We report an upper limit on the flux of relativistic monopoles based on the non-observation of in-ice showers by the Radio Ice Cherenkov Experiment (RICE) at the South Pole. We obtain a 95% C.L. limit of order 10^{-18}/(cm^2-s-sr) for intermediate mass monopoles of 10^7<gamma<10^{12} at the anticipated energy E=10^{16} GeV. This bound is over an order of magnitude stronger than all previously published experimental limits for this range of boost parameters gamma, and exceeds two orders of magnitude improvement over most of the range. We review the physics of radio detection, describe a Monte Carlo simulation including continuous and stochastic energy losses, and compare to previous experimental limits.Comment: 16 pages, 6 figures. Accepted for publication in Phys. Rev. D. Minor revisions, including expanded discussion of monopole energy uncertaint

All-sky Measurement of the Anisotropy of Cosmic Rays at 10 TeV and Mapping of the Local Interstellar Magnetic Field

We present the first full-sky analysis of the cosmic ray arrival direction distribution with data collected by the High-Altitude Water Cherenkov and IceCube observatories in the northern and southern hemispheres at the same median primary particle energy of 10 TeV. The combined sky map and angular power spectrum largely eliminate biases that result from partial sky coverage and present a key to probe into the propagation properties of TeV cosmic rays through our local interstellar medium and the interaction between the interstellar and heliospheric magnetic fields. From the map, we determine the horizontal dipole components of the anisotropy δ 0h = 9.16 × 10−4 and δ 6h = 7.25 × 10−4 (±0.04 × 10−4). In addition, we infer the direction (229fdg2 ± 3fdg5 R.A., 11fdg4 ± 3fdg0 decl.) of the interstellar magnetic field from the boundary between large-scale excess and deficit regions from which we estimate the missing corresponding vertical dipole component of the large-scale anisotropy to be ${\delta }_{N}\sim -{3.97}_{-2.0}^{+1.0}\times {10}^{-4}$

How much input is nedded from the microstructure to model ductile fracture?

International audienceNew phenomena of ductile behavior are briefly presented that are mostly relevant for anisotropic materials. These include void rotation induced ductility enhancement under off-axes loading and two modes of coalescence that are different from the internal necking mode. The effects associated with some phenomena are of first order and the general question arises as to what microstructural parameters affect ductile behavior